Product Name :
NH2-PEG2-C2-Boc
Description:
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CAS:
756525-95-8
Molecular Weight:
233.30
Formula:
C11H23NO4
Chemical Name:
tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
Smiles :
CC(C)(C)OC(=O)CCOCCOCCN
InChiKey:
XIVHGTLMLORWEP-UHFFFAOYSA-N
InChi :
InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sarolaner} web|{Sarolaner} Parasite|{Sarolaner} Protocol|{Sarolaner} References|{Sarolaner} custom synthesis|{Sarolaner} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Colistin} site|{Colistin} Autophagy|{Colistin} Protocol|{Colistin} Formula|{Colistin} custom synthesis|{Colistin} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:26446225
Additional information:
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).|Product information|CAS Number: 756525-95-8|Molecular Weight: 233.30|Formula: C11H23NO4|Chemical Name: tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate|Smiles: CC(C)(C)OC(=O)CCOCCOCCN|InChiKey: XIVHGTLMLORWEP-UHFFFAOYSA-N|InChi: InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|Products are for research use only. Not for human use.|