Ce of any evidence of plaque rupture, OCTerosion, or OCTCN, spontaneous
Ce of any evidence of plaque rupture, OCTerosion, or OCTCN, spontaneous coronary artery dissection (SCAD) (supplemental Figure 2), coronary spasm (supplemental Figure three), and fissure (supplemental Figure 4). Tissue characteristics of underlying plaque were defined using previously established criteria (79). Plaques had been classified as: (i) fibrous (homogeneous, higher backscattering area) or (ii) lipid (lowsignal region with diffuse border). For each and every lipid plaque, the maximal lipid arc was measured. Lipid length was recorded on a longitudinal view. Thincap fibroatheroma (TCFA) was defined as a plaque with lipid content material in two quadrants and the thinnest part of the fibrous cap measuring 65 m. Intracoronary thrombus was definedNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptJ Am Coll Cardiol. Author manuscript; out there in PMC 204 November 05.Jia et al.Pageas a mass (diameter 250 m) attached towards the luminal surface or floating inside the lumen, which includes red (red blood cellrich) thrombus, defined by high backscattering and higher attenuation, or white (plateletrich) thrombus, defined by homogeneous backscattering with low attenuation. Calcification was defined as an location with low backscattering signal as well as a sharp border inside a plaque. Microchannels have been defined as signalpoor voids that were sharply delineated in numerous contiguous frames (9). Interobserver and intraobserver variability were assessed by the evaluation of all photos by two independent observers and by the same observer at two separate time points, respectively. The interobserver Kappa coefficients for thrombus, PR, definite OCTerosion, probable OCTerosion, and OCTCN had been 0.860, 0.885, 0.96, 0.877, and 0.927, respectively. The intraobserver Kappa coefficients for thrombus, PR, definite OCTerosion, probable OCTerosion, and OCTCN had been 0.953, 0.952, 0.970, 0.884, and .000, respectively. Quantitative Coronary Angiography (QCA) Coronary angiograms were analyzed using the Cardiovascular Angiography Evaluation System (CAAS 5.0, Pie Medical Imaging B.V Maastricht, The Netherlands). The reference diameter, minimum lumen diameter, diameter stenosis, region stenosis, and lesion length have been measured. Statistical AnalysisNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptAll statistical analyses had been performed by an independent statistician in the Core Laboratory. Categorical variables were presented as counts and GSK-2881078 web proportions, plus the comparisons had been performed using a Fisher’s exact test. Continuous variables were presented as mean normal deviation (SD). The indicates on the continuous measurements have been examined utilizing the independent samples ttest for twogroup comparisons, and Analysis of Variance (ANOVA) for threegroup comparisons (plaque rupture, OCTerosion, and OCTcalcified nodule) followed by posthoc test protected general significance degree of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25361489 0.05. A Bonferroni’s correction was used to handle for several comparisons amongst the three groups (plaque rupture, OCTerosion, and OCTcalcified nodule). All statistical analyses were performed with SPSS 7.0 (SPSS Inc Chicago, IL). All pvalues had been twosided.ResultsBaseline Demographics and Laboratory Benefits The clinical traits of classified patients (PR, OCTerosion or OCTCN) and patients with other atypical lesion characteristics are summarized in Table . There were no significant variations in all of the clinical characteristic variables between the two groups. The comparison of patient charac.