Product Name :
PS315
Description:
PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity.
CAS:
1221964-50-6
Molecular Weight:
362.85
Formula:
C23H19ClO2
Chemical Name:
(2Z)-3-[1,1′-biphenyl]-4-yl-5-(4-chlorophenyl)pent-2-enoic acid
Smiles :
OC(=O)/C=C(/CCC1C=CC(Cl)=CC=1)\C1C=CC(=CC=1)C1C=CC=CC=1
InChiKey:
KXEKGLNMBLODQT-PGMHBOJBSA-N
InChi :
InChI=1S/C23H19ClO2/c24-22-14-7-17(8-15-22)6-9-21(16-23(25)26)20-12-10-19(11-13-20)18-4-2-1-3-5-18/h1-5,7-8,10-16H,6,9H2,(H,25,26)/b21-16-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Nourseothricin Bacterial
Shelf Life:
≥12 months if stored properly.Anti-Mouse CD117 Antibody c-Kit
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32310499
Additional information:
PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity.|Product information|CAS Number: 1221964-50-6|Molecular Weight: 362.85|Formula: C23H19ClO2|Chemical Name: (2Z)-3-[1,1′-biphenyl]-4-yl-5-(4-chlorophenyl)pent-2-enoic acid|Smiles: OC(=O)/C=C(/CCC1C=CC(Cl)=CC=1)\C1C=CC(=CC=1)C1C=CC=CC=1|InChiKey: KXEKGLNMBLODQT-PGMHBOJBSA-N|InChi: InChI=1S/C23H19ClO2/c24-22-14-7-17(8-15-22)6-9-21(16-23(25)26)20-12-10-19(11-13-20)18-4-2-1-3-5-18/h1-5,7-8,10-16H,6,9H2,(H,25,26)/b21-16-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Preincubation of U937 cells with 5 μM PS315 inhibits TNF-α induced NF-κB activation by 74%, whereas complete inhibition is observed with 10 μM PS315. The small allosteric inhibitor PS315 and the N-terminal region of aPKC both act directly on the PIF-pocket on-off switch. PS315, binding at the PIF-pocket, induces a displacement of the active site residue Lys111, thereby inhibiting the activity of aPKCs by allosterically affecting the catalytic mechanism of the kinase.|Products are for research use only. Not for human use.|