Product Name :
LP-922761
Description:
LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.
CAS:
1454808-95-7
Molecular Weight:
410.47
Formula:
C21H26N6O3
Chemical Name:
tert-butyl N-(2-{[3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl]amino}ethyl)-N-methylcarbamate
Smiles :
CN(CCNC1C=CC2=NC=C(C3C=CC(=CC=3)C(N)=O)N2N=1)C(=O)OC(C)(C)C
InChiKey:
YNQNYIHMAZLJAV-UHFFFAOYSA-N
InChi :
InChI=1S/C21H26N6O3/c1-21(2,3)30-20(29)26(4)12-11-23-17-9-10-18-24-13-16(27(18)25-17)14-5-7-15(8-6-14)19(22)28/h5-10,13H,11-12H2,1-4H3,(H2,22,28)(H,23,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amifostine} MedChemExpress|{Amifostine} MDM-2/p53|{Amifostine} Technical Information|{Amifostine} References|{Amifostine} supplier|{Amifostine} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.|Product information|CAS Number: 1454808-95-7|Molecular Weight: 410.47|Formula: C21H26N6O3|Chemical Name: tert-butyl N-(2-{[3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl]amino}ethyl)-N-methylcarbamate|Smiles: CN(CCNC1C=CC2=NC=C(C3C=CC(=CC=3)C(N)=O)N2N=1)C(=O)OC(C)(C)C|InChiKey: YNQNYIHMAZLJAV-UHFFFAOYSA-N|InChi: InChI=1S/C21H26N6O3/c1-21(2,3)30-20(29)26(4)12-11-23-17-9-10-18-24-13-16(27(18)25-17)14-5-7-15(8-6-14)19(22)28/h5-10,13H,11-12H2,1-4H3,(H2,22,28)(H,23,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 41.{{Octreotide} medchemexpress|{Octreotide} Neuronal Signaling|{Octreotide} Technical Information|{Octreotide} Purity|{Octreotide} supplier|{Octreotide} Autophagy} 67 mg/mL (101.PMID:32407179 52 mM; ultrasonic and warming and heat to 80°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment.|Products are for research use only. Not for human use.|