Product Name :
Macropa-NCS
Description:
Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. A promising therapeutic radionuclide applied in the treatment of soft-tissue metastases.
CAS:
2146095-31-8
Molecular Weight:
589.66
Formula:
C27H35N5O8S
Chemical Name:
6-({16-[(6-carboxypyridin-2-yl)methyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl}methyl)-4-isothiocyanatopyridine-2-carboxylic acid
Smiles :
OC(=O)C1C=C(C=C(CN2CCOCCOCCN(CC3C=CC=C(N=3)C(O)=O)CCOCCOCC2)N=1)N=C=S
InChiKey:
PKCFWCMMZOUICG-UHFFFAOYSA-N
InChi :
InChI=1S/C27H35N5O8S/c33-26(34)24-3-1-2-21(29-24)18-31-4-8-37-12-14-39-10-6-32(7-11-40-15-13-38-9-5-31)19-23-16-22(28-20-41)17-25(30-23)27(35)36/h1-3,16-17H,4-15,18-19H2,(H,33,34)(H,35,36)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Trastuzumab} web|{Trastuzumab} Protein Tyrosine Kinase/RTK|{Trastuzumab} Technical Information|{Trastuzumab} Formula|{Trastuzumab} manufacturer|{Trastuzumab} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Anti-Mouse CTLA-4 Antibody} site|{Anti-Mouse CTLA-4 Antibody} Immunology/Inflammation|{Anti-Mouse CTLA-4 Antibody} Protocol|{Anti-Mouse CTLA-4 Antibody} In Vitro|{Anti-Mouse CTLA-4 Antibody} custom synthesis|{Anti-Mouse CTLA-4 Antibody} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. A promising therapeutic radionuclide applied in the treatment of soft-tissue metastases.|Product information|CAS Number: 2146095-31-8|Molecular Weight: 589.66|Formula: C27H35N5O8S|Chemical Name: 6-({16-[(6-carboxypyridin-2-yl)methyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl}methyl)-4-isothiocyanatopyridine-2-carboxylic acid|Smiles: OC(=O)C1C=C(C=C(CN2CCOCCOCCN(CC3C=CC=C(N=3)C(O)=O)CCOCCOCC2)N=1)N=C=S|InChiKey: PKCFWCMMZOUICG-UHFFFAOYSA-N|InChi: InChI=1S/C27H35N5O8S/c33-26(34)24-3-1-2-21(29-24)18-31-4-8-37-12-14-39-10-6-32(7-11-40-15-13-38-9-5-31)19-23-16-22(28-20-41)17-25(30-23)27(35)36/h1-3,16-17H,4-15,18-19H2,(H,33,34)(H,35,36)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23880095 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|A stock solution containing 4.4 mg/mL of macropa-NCS was prepared in 0.1 M pH 9.1 NaHCO3 buffer containing 0.154 M NaCl and was stored at -80 °C. To a portion of Tmab in saline (74 μL) were added macropa-NCS (52 μL) and NaHCO3 buffer (266 μL), so that the final concentrations of Tmab and macropa-NCS were 5.1 mg/mL and 0.59 mg/mL, respectively. Macropa-NCS was estimated to be in 16-fold molar excess to Tmab based on a molecular weight of 1045.76 g/mol for macropa-NCS (tetra-TFA salt).|Products are for research use only. Not for human use.|