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Original ArticlePrognostic significance of vascular endothelial growth factor expression in hepatocellular carcinoma tissue: a meta-analysisPing Zhan1,2, Qian Qian1, Li-Ke YuFirst Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing 210029, China; 2The Collaborative Analysis (CORE) Group, Sydney,Australia Corresponding to: Li-Ke Yu. 1st Division of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing 210029, China. Email: [email protected]: Vascular endothelial development aspect (VEGF) is regarded as a prime mediator of angiogenesis,and has been implicated in carcinogenesis and metastasis. Numerous research examined the partnership amongst VEGF overexpression together with the clinical outcome in sufferers with hepatocellular carcinoma (HCC), but yielded conflicting results.Strategies: Electronic databases updated to June 2013 were searched to seek out relevant research. A meta-analysis was conducted with eligible studies which quantitatively evaluated the connection among VEGF overexpression and survival of sufferers with HCC. Survival information were aggregated and quantitatively analyzed.Results: We performed a meta-analysis of 14 studies that evaluated the correlation between VEGFoverexpression and survival in sufferers with HCC. Combined hazard ratios recommended that VEGF overexpression had an unfavorable effect on general survival (OS) [hazard ratio (HR) =1.42, 95 self-assurance interval (CI): 1.42-1.7], but not disease cost-free survival (DFS) (HR=1.13, 95 CI: 0.PS10 manufacturer 89-1.DPPC Formula 38) in sufferers with HCC.PMID:34235739 No substantial heterogeneity (P=0.949) was observed among 9 research for OS, nonetheless important heterogeneity (P=0.008) was observed amongst 11 studies for DFS.Conclusions: VEGF overexpression indicates a poor prognosis for sufferers with HCC. Important Words: Vascular endothelial growth factor (VEGF); hepatocellular carcinoma (HCC); prognosis; metaanalysis Submitted Jun 01, 2013. Accepted for publication Jun 21, 2013. doi: 10.3978/j.issn.2304-3881.2013.06.06 Scan to your mobile device or view this article at: http://www.thehbsn.org/article/view/2216/Introduction Hepatocellular carcinoma (HCC) is definitely the sixth most typical cancer plus the third most typical cause of death from cancer along with the third biggest cause of cancer-related deaths worldwide (1). Despite the fact that liver resection is definitely an.