Her’s exact test (sex, organomegaly). P-value from Pearson’s chi-square
Her’s exact test (sex, organomegaly). P-value from Pearson’s chi-square test for Hasford threat category and overall performance status. Unknowns have been excluded from significance tests. Pts=patients.NIH-PA Author ManuscriptPageNIH-PA Author ManuscriptNIH-PA Author ManuscriptBr J Haematol. Author manuscript; offered in PMC 2015 January 01.TableTreatment IL-4 Protein Species outcomes of 145 CML-CP patients by remedy arm.IM400 (N=72) Pts 59 63 four 5 N=49 33 N=45 N=53 67 520 35 85 714 0.040 N=41 7 four five 6 24 3 four 12 0.49 88 784 66 90 816 0.38 82 710 62 85 752 0.40 95 CI Pts 95 CI P IM800 (N = 73)Complete haematologic response (confirmed)Full haematologic response (any)Resistant diseaseNot evaluableComplete cytogenetic responseMolecular response at 1 year : 16 four 4 9 21 10 19 92 0.13 9 21 14 26 150 0.023 36 221 28 53 397 0.3-log reduce (MMR)4-log decrease(MR4.0)4.5-log decrease(MR4.5)One-sided p-value from Fisher’s precise test for superior outcome within the IM800 arm.Br J Haematol. Author manuscript; out there in PMC 2015 January 01.Based on blood specimens collected 29506 days just after randomization (if a patient’s molecular response was tested much more than after in the course of that MIG/CXCL9 Protein supplier interval, only the result obtained closest to day 365 was included in this analysis).NIH-PA Author ManuscriptDeininger et al. PageNIH-PA Author ManuscriptNIH-PA Author ManuscriptTableTreatment outcomes of 111 individuals with CML-CP as outlined by molecular response at 3 monthsIM400 10 (N=19) Pts 18 0 N=15 6 N=10 1 0 0 0 01 three 11 29 0.38 0 0 04 ten 29 156 0 01 three 11 29 0.38 0 0 04 14 40 248 10 05 11 41 221 0.080 0 0 04 26 74 576 0.0001 0.020 0.074 N=27 N=9 N=35 40 168 23 85 666 0.0038 3 50 128 25 93 769 0.031 N=27 N=6 N=28 3 1 1 95 7400 33 92 768 0.83 9 82 488 44 98 8800 0.095 95 CI Pts 95 CI P Pts 95 CI Pts 95 CI P 10 (N=36) ten (N=11) ten (N=45) IMCHRNot evaluableCCyRMR at 1 year3-log (MMR)4-log(MR4.0)four.5-log(MR4.5)One-sided p-value for poorer outcome in patients with 10 reduction in transcript at 3 months, based on Fisher’s precise test.Incorporates 84 CHRs (40 IM400, 44 IM800) achieved on or prior to collection of 3-month specimen.All CCyRs have been accomplished following day 90 specimen collection, except one IM400 patient 4 with ten Reduction.Br J Haematol. Author manuscript; obtainable in PMC 2015 January 01.Based on blood specimens collected 29506 days soon after randomization (if a patient’s molecular response was tested far more than once through that interval, only the result obtained closest to day 365 was included in this analysis).NIH-PA Author ManuscriptDeininger et al. PageNIH-PA Author ManuscriptNIH-PA Author ManuscriptTableToxicities of 144 CML-CP individuals who received assigned therapy, by treatment armIM400 (N=72) All grades Haematologic toxicities 47 (65 ) 23 (32 ) 1 ( 1 ) 24 (33 ) Fluid retention 42 (58 ) 0 ( 0 ) Gastrointestinal toxicities 28 (39 ) 36 (50 ) 11 (15 ) 11 (15 ) Other non-haematologic toxicities 47 (65 ) 33 (46 ) 19 (26 ) 9 (13 ) 3 ( four ) 0 ( 0 ) 7 (ten ) 0 ( 0 ) 0.14 1 ( 1 ) 9 (13 ) 1 ( 1 ) 0.49 1 ( 1 ) 36 (50 ) 4 ( six ) 0.0012 two ( 3 ) 42 (58 ) eight (11 ) 0.011 0 ( 0 ) 57 (79 ) 11 (15 ) 0.0006 0 ( 0 ) 16 (22 ) 0 ( 0 ) 0.16 1 ( 1 ) 20 (28 ) 0 ( 0 ) 0.036 2 ( three ) 42 (58 ) 2 ( 3 ) 0.043 1 ( 1 ) 40 (56 ) 6 ( 8 ) 0.0088 0 ( 0 ) two ( 3 ) 0 ( 0 ) 0.25 3 ( four ) 50 (69 ) 2 ( three ) 0.15 six ( eight ) 46 (64 ) 14 (19 ) 0.0001 1 ( 1 ) 1 ( 1 ) 1 ( 1 ) 0.75 eight (11 ) 33 (46 ) 12 (17 ) 0.043 5 ( 7 ) 59 (82 ) 8 (11 ) 0.0067 Grade three All grades Grade three P I.