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Zhang et al. Parasites Vectors (2015)8:37 DOI ten.1186/s13071-015-0650-RESEARCHOpen AccessAn association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicumWeiwei Zhang1, Jifeng Zhu1, Xian Song1, Zhipeng Xu1, Xue Xue2, Xiaojun Chen1, Xiaowei Yang1, Yong Li1, Xiaoxiao Dong1, Sha Zhou1, Wei Li1, Yingying Qian3, Feng Liu1 and Chuan Su1AbstractBackground: Schistosomiasis can be a chronic parasitic disease that affects approximately 200 million men and women. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4+T cell responses to regulate the formation on the granulomas. Subsequently, excessive granulomatous response in some heavily, and/or repeatedly infected people could lead to chronic liver fibrosis and circulatory impairment. Hence, elucidation on the mechanisms of those responses will not only supply far more data to superior comprehend the mechanisms of the immunoregulation in schistosomiasis, but in addition enable to style new therapies to manage granuloma-associated immunopathology. The part of aquaporin-4 (AQP4) in water transport has been extensively investigated in the central nervous technique (CNS). Lately, studies have shown that AQP4 expresses in immune method and lack of AQP4 in mice outcomes in considerably less CD4+CD25+ T regulatory cells (Treg cells) under physiological condition, among the subpopulations of CD4+T cells which restrains immunopathology in hosts with schistoso.