Kg/m2 Physical activity, metabolic equivalent 18.five 6 22.eight 18.0 six 22.five task-h/wk Family members history of diabetes, n ( ) 43,178 (31.3) 33,565 (31.three) Menopausal status, n ( ) Premenopausal 66,226 (48.0) 52,865 (49.3) PROTACs Inhibitor drug Postmenopausal, no hormone use 14,295 (10.four) 11,043 (10.three) Postmenopausal, past hormone use 19,162 (13.9) 14,658 (13.7) Postmenopausal, present hormone use 29,442 (21.3) 21,798 (20.three) Missing worth 8831 (six.4) 6969 (six.5) History of hypertension, n ( ) 33,470 (24.three) 26,189 (24.4) History of hypercholesterolemia, n ( ) 52,174 (37.8) 40,347 (37.6) Present smoker, n ( ) 13,332 (9.7) ten,910 (ten.2) White, n ( ) 133,828 (97.0) 104,104 (97.0) Multivitamin use, n ( ) 67,124 (48.7) 51,650 (48.1) Alcohol consumption, g/d 4.5 six eight.2 4.five 6 8.two Total energy intake, kcal/d 1790 six 558 1730 six 540 Complete grain intake, g/d 27.five six 18.two 27.three six 18.4 Red/processed meat intake, g/d 60.six six 45.4 59.7 six 44.six Fish intake, g/d 18.9 six 19.0 17.8 six 18.3 Poultry intake, g/d 58.5 6 45.1 57.eight 6 44.8 Vegetable intake, g/d 245 six 153 232 6 145 Fruit intake, g/d 161 6 124 152 six 121 Coffee, g/d 389 six 372 389 six 372 Sugar-sweetened beverage, g/d 158 six 302 162 6 310 Fiber, g/d 19.7 6 six.0 19.4 six 5.9 Glycemic load 122 six 24 123 six 24 Total fats, g/d 57.3 six 14.two 56.six 6 14.2 PUFA to SFA ratio 0.58 six 0.20 0.58 6 0.20 a-Linolenic acid, g/d 1.00 6 0.36 0.93 six 0.31 Magnesium, mg/d 348 6 97 345 six 98 Arginine, g/d 4.04 6 0.85 4.03 6 0.86 Walnut intake, g/d 0.56 six 2.24 060 Peanut intake, g/d 1.40 six 3.92 1.12 six 3.36 Other nut intake, g/d 1.12 6 three.64 0.84 six three.36 Total nut intake, g/d 3.36 6 3.92 1.96 6 5.,0.001 48.1 ,0.001 0.56 ,0.001 0.ten ,0.001 ,0.001 0.01 ,0.001 ,0.001 ,0.001 ,0.001 0.79 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.Information are imply six SD or n ( ) as specified. 1 serving of walnuts = 28 g.respectively (P-trend = 0.002). Each 2-servings/wk increment of walnut BChE Formulation intake was linked with 21 (13?9 ) and 15 (6?23 ) lower risk of incident type two diabetes before and immediately after adjustment for BMI, respectively. The associations had been comparable to adjustments for saturated fat, trans fat, glycemic load, and cereal fiber instead of adjustment for meals variables, and further adjustment for PUFAs, a-linolenic acid, total fiber, magnesium, and arginine did not modify the outcomes (data not shown). We did not find any interaction amongst walnut consumption and obesity status, physical activity, dietary high quality, and loved ones history of diabetes inside the risk of form 2 diabetes (information not shown). For other tree nuts, we also found an inverse association with danger of kind 2 diabetes. In the multivariable-adjusted model without having BMI, the pooled HRs (95 CIs) for participants consuming 1? servings/mo, 1 serving/wk, and 2 servings/wk of other tree nuts have been 0.99 (0.94?.06), 0.93 (0.83?.04), and 0.88 (0.77?.99) compared with ladies who never/rarely514 Pan et al.consumed other tree nuts (P-trend = 0.03). On the other hand, the association was attenuated to null just after additional adjustment for BMI. We further examined the relation of total nut (including peanut, walnut, as well as other nuts) and peanut intakes with threat of variety two diabetes (Table 3). Total nut consumption was associated having a decrease risk of incident variety 2 diabetes ahead of adjustment for BMI in each cohorts. Within the pooled evaluation, the HRs (95 CIs) for participants consuming 1? servings/mo, 1 serving/wk, two? servings/wk, and five servings/wk of total nuts had been 0.96 (0.92?.01), 0.95 (0.89?.02), 0.89 (0.80?.98), and 0.84 (0.75?.93), re.