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Redox Biology two (2014) 739Contents lists accessible at ScienceDirectRedox Biologyjournal homepage: elsevier.com/locate/redoxResearch PaperDifferent style of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative variations in biological activities with regards to toxicity and inflammationE. Stamellou a,b,1,n, D. Storz b,1, S. Botov c, E. Ntasis b, J. Wedel b, S. Sollazzo c, B.K. Kr er b, W. van Son d, M. Seelen d, H.G. Schmalz c, A. Schmidt c, M. Hafner a, B.A. Yard baInstitute for Molecular and Cellular Biology, Mannheim University of Applied Sciences, Mannheim, Germany Vth. Health-related Department, Medical Faculty Mannheim, Ruprecht Karls University, Heidelberg Mannheim, Germany Division of Chemistry, University of Cologne, Cologne, Germany d Division of Nephrology, Academic Healthcare Center, Groningen, The Netherlandsb cart ic l e i nf oArticle history: Received 7 May perhaps 2014 Received in revised kind 29 May 2014 Accepted two June 2014 Offered on the net five June 2014 Search phrases: Endothelial cells Carbon monoxide Adhesion molecules Enzyme-triggered CORMsa b s t r a c tAcyloxydiene e(CO)three complexes can act as enzyme-triggered CO-releasing molecules (ET-CORMs). Their biological activity strongly depends upon the mother compound from which they’re derived, i.e. cyclohexenone or cyclohexanedione, and around the position of the ester functionality they harbour. The present study addresses when the latter characteristic affects CO release, if cytotoxicity of ET-CORMs is mediated by means of iron release or inhibition of cell respiration and to what extent cyclohexenone and cyclohexanedione derived ET-CORMs differ in their capability to counteract TNF- mediated inflammation. Irrespective with the formulation (DMSO or cyclodextrin), toxicity in HUVEC was PIM2 Storage & Stability substantially higher for ET-CORMs bearing the ester functionality at the outer (rac-4), as compared to the inner (rac-1) position of your cyclohexenone moiety. This was paralleled by an improved CO release in the former ET-CORM. Toxicity was not mediated via iron as EC50 values for rac-4 had been substantially decrease than for FeCl2 or FeCl3 and have been not influenced by iron chelation. ATP depletion preceded toxicity suggesting impaired cell respiration as putative result in for cell death. In long-term HUVEC cultures inhibition of VCAM-1 expression by rac-1 waned in time, when for the cyclohexanedione derived rac-8 inhibition seems to improve. NFB was inhibited by each rac-1 and rac-8 independent of IB degradation. Each ET-CORMs activated Nrf-2 and consequently induced the expression of HO-1. This study further supplies a rational framework for designing acyloxydiene e(CO)3 complexes as ET-CORMs with differential CO release and biological activities. We also present a much better understanding of how these complexes have an effect on cell-biology in mechanistic terms. 2014 The Authors. Published by Elsevier B.V. This is an open access write-up beneath the CC BY-NC-ND licens.