ds, including chemical, physical, and bio-based green strategies (sunlight irradiation, from bacteria, fungi, yeast, algae, and plants) [110]. As currently mentioned above, top-down and bottom-up approaches are amongst the easiest. Due to the reality that inorganic nanoparticles are already used in diagnostic medicine and imaging, scaling up their production is a reality, despite the fact that not free from costs. As they consist of a repetition of monomeric interior units encircled by the outermost region, dendrimers are usually synthesized by a sequential repeat of reaction methods. Certainly, they may be formed of a core, from which many spacers depart, whose ends combine with a high degree of branching that permits surface DOT1L Inhibitor list chemistry functionalization with proteins, amino acids, fatty acids, and polymers so as to enhance solubility and lessen toxicity [184,185]. The usage of dendrimers as drug carriers continues to be the topic of study, even though current applications consist of nanomedicines, gene-delivery vectors, biological adhesives, and imaging agents [137,18588]. Lastly, SMEDDSs belong towards the emulsion class since they may be dry microemulsions without the need of an aqueous phase and they have the good benefit to spontaneously form emulsions in vivo without any power input [86,137]. According to their higher targeting efficiency, it truly is possible to decrease the drug amount expected to have a clinical impact, thereby improving patient compliance along with the cost of therapy [137]. Taking these evaluations into account and taking into consideration the absence of information with regards to some aspects of your newest drug delivery approaches, it’s appropriate to affirm that nanoemulsions are, at present, probably the most suitable, well-investigated, and low-cost approach to improve bioavailability of curcumin, either as a drug or maybe a dietary supplement to enrich food and beverages. 4. Conclusions Presently, the polyphenolic compound curcumin is among the most investigated organic solutions and its helpful effects in numerous human disorders have been established, in addition to a low toxic profile. Through the years, several curcumin drug targets have been described, providing the molecular basis for the pharmacological action. Unfortunately, the bioavailability and delivery of curcumin will be the main obstacles for its effectiveness, precluding the use in medicine. Within this critique, we have explored probably the most promising and modern day tactics for improving curcumin bioavailability, supplying a comprehensive overview with regards to this field. Surely, the progress inside the nanoparticle field could give, within the near future, additional curcumin-based complexes with substantial pharmacological profiles that can be created as efficient therapeutic agents for treating human illnesses. The advancement in this field holds great guarantee to employ this polyphenol in medicine. Additionally, because of the multifunctional profile of curcumin, an efficacious delivery strategy may well provide a superior H3 Receptor Agonist Source possibility of efficient prophylaxis or remedy in complicated multifactorial disorders, such as systemic inflammatory diseases and cancer, supporting the curcumin-based agents as preventive and disease-modifying therapeutics.Pharmaceutics 2021, 13,29 ofAuthor Contributions: Conceptualization, R.T., S.B. and V.C.; investigation, R.T. and S.B.; information curation, R.T., S.B. and V.C.; writing–original draft preparation, R.T. and S.B.; writing–review and editing, R.T., S.B. and V.C.; supervision, S.B. All authors have read and agreed to the published version on the man