Hat “everything seems to become specifically within the suitable spot,because it need to be.” 1 patient (patient ,Picard,even explained that,though listening to a discussion in between numerous individuals throughout an ecstati aura,he felt as though he had a sudden full understanding in the subject,”as an access towards the resolution.” We hypothesize that inside the ecstatic auras the mechanisms of interoceptive prediction error generation are blocked,the comparator amongst the actual plus the predicted state no longer functions,and that there isn’t any much more mismatch. This may well lead for any handful of seconds to a pathologicallyinduced (epileptic) “stable state” without having any generated prediction error,without ambiguity,causing a feeling of certainty and intense serenity and inner peace (Picard Picard and Kurth.Heightened Self wareness and Atmosphere PerceptionsSalience and Practical experience of TimeEcstatic seizures are dominated by a feeling of a conscious selfpresence,characterized by a heightened selfawareness,plus a feeling of union with all the world,the “All,” with breakdown from the barrier involving the topic and surroundings. The anterior insula participates within the selfreflective network,preserving a coherent firstperson viewpoint,around the basis of its connections toward inferior parietal lobe and temporoparietal junction (Augustine Craig,b; Modinos et al. Dennis et al. Ionta et al. Somatosensory stimuli,as other internal and external stimuli,are processed in the posterior insula and cognitively integrated more anteriorly in the insula (Craig. An ictal hyperactivation of this area will alter this processing and could provoke abnormal unpleasant feelings (Isnard et al,or in rare instances really pleasant ones (Williams Stefan et al,with often even a feeling of sensory overload,as some individuals report. Likely in connection with its function in interoception and autonomic function,the anterior insula is specifically sensitiveFrontiers in Behavioral Neuroscience www.frontiersin.orgFebruary Volume ArticleGschwind and PicardAnterior Insula and Ecstatic SeizuresFIGURE Illustration with the networks implicated in salience processing,as obtained by the metaanalysis PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24687012 tool Neurosynth.org (Yarkoni et al,depending on the results of published research,employing the only keyword “salience” in forward inference,and displayed on a template anatomical T image with Zvalues of to (making use of the Mango computer software EMA401 web package. The resulting important regions (p FDR corrected) interestingly comprise 4 networks: Yellow: anterior cingulate cortex (ACC) and anterior insula (AI) represent the salience network (Seeley et al b). Orange: the extended insular network consisting of amygdala (AM),ventral striatum (vS),periaqueductal gray (PAG),and dorsomedial thalamus (dmTHal). Green: the PCCVMPFC represents the default mode network (Greicius et al. Blue: the frontoparietal executive manage network (Corbetta and Shulman Fox et al. The salience network is thought to switch back and forth between the default mode network and executive manage network (Menon and Uddin Uddin.to salient internal and environmental events,i.e behaviorallyrelevant stimuli,together with the dorsal anterior cingulate cortex (dACC) within the “salience network” (Seeley et al b; Eckert et al. Menon and Uddin Wiech et al. Uddin. This network detects and evaluates salient signals in order to continuously resolve uncertainty and adapt the behavior,by driving autonomic reflexes (which in turn engage feelings). As already talked about in Bliss,Clarity,and Intense SerenityEmotion Regulati.