Engagement of the TCR induces the translocation of a number of molecules this sort of as Lck, ZAP-70 and CD3f to the detergent-insoluble membrane portion of T cells that contains lipid rafts
Reliable with these earlier observations, following conjugation with APCs we discovered in WT CD8+ cells that Lck translocated to the IS exactly where it co-localized with ZAP-70 (Fig. 2A). In…