= 0.010), major vascular events (RR = 0.95, 95 CI: 0.930.98, p = 0.001), nonfatal myocardial infarction (RR = 0.89, 95 CI: 0.83.95, p = 0.001) and all-cause mortality (RR = 0.95, 95 CI: 0.92.99, p = 0.025) [195]. The REDUCE-IT study substantially changed the view on omega-3 fatty acids and their use in treatment of hypertriglyceridaemia. In December 2019, the FDA approved an icosapent ethyl formulation (Vazkepa) for therapy of hypertriglyceridaemia as a way to minimize cardiovascular risk in high-risk individuals [196]. In January 2021, the Committee forArch Med Sci six, October /M. Banach, P. Burchardt, K. Chlebus, P. Dobrowolski, D. Dudek, K. Dyrbu, M. Gsior, P. Jankowski, J. J iak, L. Klosiewicz-Latoszek, I. Kowalska, M. Malecki, A. Prejbisz, M. Rakowski, J. Rysz, B. Solnica, D. Sitkiewicz, G. Sygitowicz, G. Sypniewska, T. Tomasik, A. Windak, D. Zozuliska-Zi kiewicz, B. CybulskaMedicinal Solutions for Human Use (CHMP) on the European Medicines Agency (EMA) adopted a constructive opinion recommending promoting authorisation of Vazkepa to cut down the risk of cardiovascular events in individuals at high cardiovascular threat [196]. Hence, currently we advise the use of omega-3 acids (in Poland Vazkepa continues to be unavailable, and combined formulations of omega-3 acids in a dose of significantly less than 1 g are dominant) in remedy of hypertriglyceridaemia in a dose of a minimum of 2 g day-to-day, as adjunct therapy to Bcl-B Biological Activity statins and fibrates, except in individuals currently working with omega-3 acids in combination with statins, in whom fibrates may be employed as a 3rd line treatment.offered on the Polish industry, along with the use of ion exchange resins is at present restricted to treatment of serious hypercholesterolaemia during pregnancy. Resins are usually not absorbed in the gastrointestinal tract and demonstrate no systemic toxicity. Even so, they normally lead to gastrointestinal adverse effects (constipation, flatulence, nausea). They lessen absorption of fat-soluble vitamins. To prevent reduced absorption of other medicines, ion exchange resins really should be taken four h prior to or 1 h following other medicines. Colesevelam could be the best tolerated resin [200].Important FGFR1 drug POInTS TO ReMeMBeRBile acids sequestrants in monotherapy really should be regarded as in statin-intolerant individuals and could be deemed in mixture therapy in the event the remedy aim has not been accomplished together with the maximum tolerated statin doses. Bile acids sequestrants are safe in pregnant and breast-feeding females.Key POInTS TO ReMeMBeROmega-3 polyunsaturated acids considerably decrease triglyceride concentration (by 2030 ) and hsCRP (by 120 ). In individuals with hypertriglyceridaemia statins would be the first-line agents. Addition of omega-3 acids within a dose of a minimum of 2 g to a statin as well as a fibrate could possibly be regarded in patients with persistent hypertriglyceridaemia (TG 200 mg/dl or 2.three mmol/l) despite combination therapy. If obtainable, icosapent ethyl ought to be viewed as within a dose of two two g in addition to a statin in incredibly high-risk individuals with ASCVD with persistent TG concentration 150 mg/dl.9.7. Nicotinic acidNicotinic acid (niacin) inhibits lipolysis in adipose tissue, as a result decreasing synthesis of cost-free fatty acids (FFA) and their inflow in to the liver [8, 201]. This results in reduction of your amount of FFA supplied for the liver and consequently VLDL production. Decreased VLDL synthesis in turn leads to reduced production of intermediate-density lipoprotein (IDL) and LDL [8, 201]. Also, niacin straight inhibits hepatic diacylglycerol O-acyltransferase