Regulation of Pancreatic Cancer Growth by Superoxide
K-ras mutations are present in up to 95% of pancreatic cancers, indicating their pivotal role in the molecular development of this disease. In a study using an immortalized human pancreatic…
September 2026
Tenapanor is an NHE3 inhibitor for hyperphosphatemia research
**Background** Hyperphosphatemia is a common and serious complication often associated with chronic kidney disease, where the kidneys are unable to maintain phosphate homeostasis. Elevated serum phosphate levels can lead to…
Title: Optimized Management of COVID-19 Therapeutics Through Multidisciplinary Collaboration in a Tertiary Hospital During the First Two Waves
The management of COVID-19 during the early stages of the pandemic presented unprecedented challenges for healthcare systems worldwide, particularly in balancing rapidly evolving evidence with urgent clinical needs. At the…
Prostaglandin D2 is an endogenous sleep-promoting and anti-inflammatory metabolite
**Background** Prostaglandins are a group of lipid compounds that act as local mediators in various physiological and pathological processes. Among these, Prostaglandin D2 (PGD2) is one of the major prostaglandins…
Structure of the NLRP1 Caspase Recruitment Domain Reveals Electrostatic Mechanisms for Procaspase-1 Association
The NLRP1 inflammasome plays a critical role in innate immune responses, detecting pathogens such as Bacillus anthracis and contributing to autoimmune conditions like vitiligo. Human NLRP1 uniquely contains both an…
Neflamapimod is a p38α inhibitor for inflammatory and cancer research
**Background** The p38 mitogen-activated protein kinase (MAPK) pathway plays a critical role in the regulation of pro-inflammatory cytokine production and cellular stress responses. Among its isoforms, p38α is particularly significant…
Fumaric Acid Esters Reduce Inflammation and Oxidative Stress in Transgenic Hypertensive Rats Expressing Human CRP
Fumaric acid esters (FAE), particularly dimethyl fumarate (DMF), have demonstrated significant immunomodulatory, anti-inflammatory, and antioxidant properties. This study investigated whether FAE treatment could mitigate inflammation, oxidative stress, and metabolic dysfunction…
Regulator of Calcineurin 1 Modulates Expression of Innate Anxiety and Anxiogenic Responses to Selective Serotonin Reuptake Inhibitor Treatment
Anxiety disorders represent a significant public health challenge, affecting millions worldwide. While current treatments such as selective serotonin reuptake inhibitors (SSRIs) are widely used, they often exhibit delayed onset and…
Ertugliflozin is an SGLT2 inhibitor for type 2 diabetes mellitus research
**Background** Type 2 diabetes mellitus is a chronic metabolic disorder characterized by insulin resistance and relative insulin deficiency, leading to persistent hyperglycemia. One of the primary mechanisms contributing to elevated…
An Indole Alkaloid from a Tribal Folklore Inhibits Immediate Early Event in HSV-2 Infected Cells with Therapeutic Efficacy in Vaginally Infected Mice
Herpes genitalis, caused by herpes simplex virus type 2 (HSV-2), remains a significant global public health challenge due to its lifelong latency, high transmission rate via sexual contact, and association…