AURKA Enzyme

Description:
|Introduction AURKA (Aurora Kinase A) belongs to the mitotic serine/threonine kinases family. AURKA is a cell cycle-regulated kinase which may be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. AURKA is found at the centrosome in interphase cells and at the spindle poles in mitosis. Since the AURKA expression is cell-cycle regulated, it is low in G1/S, it accumulates during G2/M, and it decreases rapidly after. AURKA is involved in important processes during mitosis and meiosis whose proper function is essential for healthy cell proliferation. In addition, AURKA plays an essential role in tumourigenesis and is overexpressed in various types of cancers. AURKA is strongly expressed in the testis, colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines and weakly in skeletal muscle, thymus and spleen. AURKA interacts with its substrates BORA and ARHGEF2, as well as with TACC1 and CPEB1. Defects in the AURKA gene cause numerical centrosome aberrations including aneuploidy. AURKA overexpression has been linked to chromosomal instability in colorectal cancer. AURKA expression may have a prognostic significance in ovarian carcinoma. |Reco|E. coli-derived. A single, non-glycosylated, polypeptide chain containing 423 amino acids (1-403) and having a molecular mass of 47.9 kDa. AURKA is fused to 20 a.a. His-Tag at N-terminus. Purity: > 95.0% as determined by SDS-|The AURKA solution containing 20 mM Tris-HCl buffer (pH 8.0), 0.5 mM DTT, 100 mM NaCl, 0.1 mM EDTA, 0.1 mM EGTA, 0.1 mM PMSF and 20% glycerol. Shipping: The product is shipped with ice |Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. |AURKA Antibodies: AURKA Polyclonal Antibody