GSTP1 Enzyme

Description:
|Introduction GSTP1 is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are believed to function in xenobiotic metabolism and have a |alpha, mu, pi, and theta. The GSTP1 enzyme acts by catalyzing the reaction of glutathione with an acceptor molecule to form a Sulfur-substituted glutathione. The reactions employing glutathione contribute the transformation of a broad range of electrophiles, including reactive products of lipid, protein, carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. The GSTP1 inactivation through CpG hypermethylation is frequent in pituitary adenomas and may be a factor in aggressive pituitary tumor behavior. GSTP1 is may be a transcriptional target of the p53 tumor suppressor gene. Single-nucleotide polymorphism in GSTP1 is linked to modified protein binding, which influence GSTP1’s contribution to carcinogen and drug metabolism, and possibly disease |E. coli-derived. A single, non-glycosylated, polypeptide chain containing 247 amino acids (1-210 a.a.) and having a molecular mass of 27.6kDa. Specific activity is Purity > 95%, by SDS-|The GSTP1 solution contains 20 mM Tris-HCl buffer (pH7.0), 30% glycerol, 1 mM EDTA and 0.1 mM PMSF. Shipping: The product is shipped at a|Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. |GSTP1 Antibodies: GSTP1 Polyclonal Antibody