Ies are what they are today. To illustrate my point, I noted earlier the role of NICE in assessing new drugs for inclusion or exclusion by the British National Health Service. NICE has judged that some number of these targeted therapies yield too little good at too high a price to justify inclusion by the NHS. Consequently, the Cameron government created a 200 million pound fund to underwrite the costs of these drugs. This was an act that many described as political opportunism. We pass over that judgment. Policy analysts estimate that if all cancer patients in the UK who could potentially benefit to any degree from these drugs were to be covered, this fund would have to have 600 million pounds. Consequently, the local Strategic Health Authorities (SHA) are charged with determining which patients will or will not have access to these drugs through this special funding mechanism. Each SHA is free to determine what criteria it will use to make such judgments, which is a problem of health care justice because of the potential for arbitrary judgments. Equally ethically problematic is the fact that the Cameron government did not provide 200 million new pounds for that fund. Instead, at least 50 million pounds were taken from home health care funding [55]. At the very least it is BMS-214662 biological activity reasonable to ask what the justice-based argument would be for that trade-off. Finally, to return to the cost issue, much of the cost of these drugs is associated with their development. If researchers are successful in discovering a truly rational combinatorial approach to the targeted of these drugs, that could result in substantial reductions in the cost of these drugs. As I am using the phrase truly rational I am suggesting methods of determining the likely success of drug combinations that are extraordinarily reliable in predicting safety and effectiveness with much smaller clinical trials. Again, we simply have to wait and see whether those engaged in such research efforts can build predictive models capable of yielding that reliable medical knowledge. In the meantime the justice issues remain relevant because the cost issues are unresolved. 5. Conclusion: Health Care Justice and Rational Democratic Deliberation I will not conclude that there is some simple and powerful moral principle that will address all the issues raised in this essay. There is not. On the Mangafodipir (trisodium) manufacturer contrary, all the conceptions of health care justice discussed above might have some reasonable relevance to the questions we have raised. However, as I have argued at length elsewhere, none of these conceptions of health care justice is capable of yielding a just enough or compassionate enough response to all the problems of health care justice related to the very complex problem of health care rationing and priority-setting [2]. All of these conceptions are too abstract to be suitably responsive to the very complex details of the problems of health care rationing in a clinical setting. To be clear, they do have moral utility, but it is limited. Among other things, it will often be unclear which of these conceptions of health care justice is most reasonable and most fitting for a particular rationing problem, such as any of the ragged edge issues raised above. Further, it is not the case that we just need to think about these issues longer and harder, bringing the right sort of expertise to bear, and then finding the fairest and most reasonable answer. It is likely closer to the truth to say that often t.Ies are what they are today. To illustrate my point, I noted earlier the role of NICE in assessing new drugs for inclusion or exclusion by the British National Health Service. NICE has judged that some number of these targeted therapies yield too little good at too high a price to justify inclusion by the NHS. Consequently, the Cameron government created a 200 million pound fund to underwrite the costs of these drugs. This was an act that many described as political opportunism. We pass over that judgment. Policy analysts estimate that if all cancer patients in the UK who could potentially benefit to any degree from these drugs were to be covered, this fund would have to have 600 million pounds. Consequently, the local Strategic Health Authorities (SHA) are charged with determining which patients will or will not have access to these drugs through this special funding mechanism. Each SHA is free to determine what criteria it will use to make such judgments, which is a problem of health care justice because of the potential for arbitrary judgments. Equally ethically problematic is the fact that the Cameron government did not provide 200 million new pounds for that fund. Instead, at least 50 million pounds were taken from home health care funding [55]. At the very least it is reasonable to ask what the justice-based argument would be for that trade-off. Finally, to return to the cost issue, much of the cost of these drugs is associated with their development. If researchers are successful in discovering a truly rational combinatorial approach to the targeted of these drugs, that could result in substantial reductions in the cost of these drugs. As I am using the phrase truly rational I am suggesting methods of determining the likely success of drug combinations that are extraordinarily reliable in predicting safety and effectiveness with much smaller clinical trials. Again, we simply have to wait and see whether those engaged in such research efforts can build predictive models capable of yielding that reliable medical knowledge. In the meantime the justice issues remain relevant because the cost issues are unresolved. 5. Conclusion: Health Care Justice and Rational Democratic Deliberation I will not conclude that there is some simple and powerful moral principle that will address all the issues raised in this essay. There is not. On the contrary, all the conceptions of health care justice discussed above might have some reasonable relevance to the questions we have raised. However, as I have argued at length elsewhere, none of these conceptions of health care justice is capable of yielding a just enough or compassionate enough response to all the problems of health care justice related to the very complex problem of health care rationing and priority-setting [2]. All of these conceptions are too abstract to be suitably responsive to the very complex details of the problems of health care rationing in a clinical setting. To be clear, they do have moral utility, but it is limited. Among other things, it will often be unclear which of these conceptions of health care justice is most reasonable and most fitting for a particular rationing problem, such as any of the ragged edge issues raised above. Further, it is not the case that we just need to think about these issues longer and harder, bringing the right sort of expertise to bear, and then finding the fairest and most reasonable answer. It is likely closer to the truth to say that often t.