Its absence (KO design or RNA knockdown experiments) or presence (in vitro assays) leads to activation or inactivation of Wnt and PI3Kinase signaling pathways marketing numerous cellular responses that effect on survival, migration and differentiation

The simple fact that LMa5 is needed for the establishment and maintenance of the smaller intestinal epithelium is also supported by the observation that rather of the normal crypt-villus morphology…