AIM-100, a small molecule inhibitor of Ack1 with an IC50 of 24 nM, nnhibitors of Ack1 activity could be novel therapeutic agents to treat AIPC.
Enhanced radiosensitization of castration-resistant prostate cells treated with AIM-100. B, castrated nude male mice were injected with unirradiated or irradiated (1.5 Gy) LNCaP-caAck-expressing cells. Mice were injected with AIM-100 (4 mg/kg of body weight per injection) on seventh day post-injection of cells (n = 8 mice for each treatment). Five injections of AIM-100 were followed on 11th, 15th, 19th, 23rd, and 27th day. Tumor volumes were measured; *, p = 0.024; **, p = 0.041.